Critical Care Research Database – 2015 Edition


This research database is a comprehensive resource through which students, residents and fellows can develop a sound understanding of major topics in the world of critical care. Read through the landmark studies, meta-analyses, and recently-published review articles we’ve carefully selected, and you’ll know everything there is to know about your topic of interest. Check back often! We’re always adding more topics.

Acid-base DisordersAn approach to complex acid-base problems: keeping it simple.Herd AMCanadian Family Physician2005
Acid-base DisordersMetabolic acidosis in the critically ill: part 1Morris CGAnesthesia2008
Acid-base DisordersMetabolic acidosis in the critically ill: part 2Morris CGAnesthesia2008
Acute Hepatic FailureHepatorenal syndrome and novel advances in its management.Fabrizi FKidney Blood Press Res2013
Acute Hepatic FailureAcute-on-chronic liver failure: current concepts on definition, pathogenesis, clinical manifestations and potential therapeutic interventions.Laleman WExpert Rev Gastroenterol Hepatol2011
Acute Hepatic FailureAcute Liver FailureBernal WNew Engl J Med2013
Alcohol WithdrawalEfficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome.Amato LCochrane Databse Sys Rev2011
Alcohol WithdrawalLorazepam for the prevention of recurrent seizures related to alcohol.D'Onofrio GNew Engl J Med1999
Alcohol WithdrawalRecognition and management of withdrawal delirium (delirium tremens).Schuckit MANew Engl J Med2014
Analgesia and SedationSedation and analgesia in the mechanically ventilated patient.Patel SBAm J Respir Crit Care Med.2012
Analgesia and SedationDaily sedation interruption versus targeted light sedation strategies in ICU patients.Hughes CGCrit Care Med2013
Analgesia and SedationDexmedetomidine: a review of its use for sedation in mechanically ventilated patients in an intensive care setting and for procedural sedation.Hoy SMDrugs2011
Analgesia and SedationRemifentanil : a review of its analgesic and sedative use in the intensive care unit.Battershill AJDrugs2006
AnaphylaxisH1-antihistamines for the treatment of anaphylaxis: Cochrane systematic review.Sheikh AAllergy2007
AnaphylaxisAdrenaline (epinephrine) for the treatment of anaphylaxis with and without shock.Sheikh ACochrane Database Sys Rev2008
AnaphylaxisGlucocorticoids for the treatment of anaphylaxis.Choo KJCochrane Database Sys Rev2012
Aortic DissectionMedical management of acute type A aortic dissection.Feldman MAnn Thorac Cardiovasc Surg2009
Aortic DissectionCurrent management of type B aortic dissection.Tran TPVasc Health Risk Manag2009
Aortic DissectionManagement of acute type B aortic dissection; ADSORB trial.Hughes GCJ Thorac Cardiovasc Surg2015
Acute Respiratory Distress SyndromeMeta-analysis: ventilation strategies and outcomes of the acute respiratory distress syndrome and acute lung injury.Putensen CAnn Intern Med2009
Acute Respiratory Distress SyndromeHigher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis.Briel MJAMA2010
Acute Respiratory Distress SyndromeThe effect of prone positioning on mortality in patients with acute respiratory distress syndrome: a meta-analysis of randomized controlled trials.Hu SLCrit Care Med2014
Acute Respiratory Distress SyndromeEfficacy and safety of corticosteroids for persistent acute respiratory distress syndrome.Steinberg KPNew Engl J Med2006
AsthmaSevere refractory asthma: an update.Wener RREur Respir Rev2013
AsthmaCorticosteroids in the treatment of acute asthmaAlangari AAAnn Thorac Med2014
AsthmaNon-invasive positive pressure ventilation for treatment of respiratory failure due to severe acute exacerbations of asthma.Lim WJCochrane Database Sys Rev2012
AsthmaKetamine in status asthmaticus: A review.Goyal SIndian J Crit Care Med2013
AsthmaManagement of mechanical ventilation in acute severe asthma: practical aspects.Oddo MIntensive Care Med2006
Chronic Obstructive Pulmonary DiseaseNoninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease.BrochardNew Engl J Med1995
Chronic Obstructive Pulmonary DiseaseDifferent durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease.Walters JACochrane Database Sys Rev2014
Chronic Obstructive Pulmonary DiseaseAntibiotics for exacerbations of chronic obstructive pulmonary disease.Vollenweider DJCochrane Database Sys Rev2012
Burn ManagementIntra-abdominal hypertension and abdominal compartment syndrome in burn patients.Ivy MEJ Trauma2000
Burn ManagementBurn resuscitation.Alvarado RBurns2009
Hemorrhagic StrokeIntracranial hemorrhage: diagnosis and management.Freeman WDNeurol Clin2012
Hemorrhagic StrokeRapid blood-pressure lowering in patients with acute intracerebral hemorrhage.Anderson CSNEJM2013
Hemorrhagic StrokeAneurysmal Subarachnoid Hemorrhage.D'Souza SJ Neurosurg Anesthesiol2014
Hemorrhagic StrokeCurrent options for the management of aneurysmal subarachnoid hemorrhage-induced cerebral vasospasm: a comprehensive review of the literature.Dabus GInterv Neurol2013
Ischemic StrokeAdvances in the Critical Care Management of Ischemic StrokeSingh VStroke Res Treat2013
Ischemic StrokeThrombolysis for acute ischaemic stroke.Wardlaw JMCochrane Database Sys Rev2014
Ischemic StrokeEffects of immediate blood pressure reduction on death and major disability in patients with acute ischemic stroke: the CATIS randomized clinical trial.He JJAMA2014
Ischemic StrokeIndications for early aspirin use in acute ischemic stroke : A combined analysis of 40 000 randomized patients from the chinese acute stroke trial and the international stroke trial. On behalf of the CAST and IST collaborative groups.Chen ZMStroke2000
Ischemic StrokeRandomized assessment of rapid endovascular treatment of ischemic stroke.Goyal MNew Engl J Med2015
Traumatic Intracranial HemorrhageCritical care management of severe traumatic brain injury in adults.Haddad SHScand J Trauma Resusc Emerg Med.2012
Traumatic Intracranial HemorrhageSpecific intensive care management of patients with traumatic brain injury: Present and futureChowdhury TSaudi J Anaesthesia2014
Diabetic Ketoacidosis/Hyperosmolar, Hyperglycemic Nonketotic SyndromeDiabetic ketoacidosis: diagnosis and management.Fasanmade OAAfr J Med Sci2008
Diabetic Ketoacidosis/Hyperosmolar, Hyperglycemic Nonketotic SyndromeHyperglycemic Crises in Adult Patients with DiabetesKitabchi AEDiabetes Care2009
Diabetic Ketoacidosis/Hyperosmolar, Hyperglycemic Nonketotic SyndromeHyperglycemic Hyperosmolar Syndrome in Children: Pathophysiological Considerations and Suggested Guidelines for TreatmentZeitler Ppediatric endocrine society2010
Heart failureThe 2012 Canadian Cardiovascular Society Heart Failure Management Guidelines Update: Focus on Acute and Chronic Heart FailureMcKelvie RSCanadian Journal of Cardiology2013
Heart failureContinuous versus bolus intermittent loop diuretic infusion in acutely decompensated heart failure: a prospective randomized trial.Palazzouli ACritical Care2014
Hyper- and Hypo- kalemiaPathogenesis, diagnosis and management of hyperkalemiaLehnhardt APediatr Nephrol2011
Hyper- and Hypo- kalemiaHyperkalemia: A ReviewGreenberg AJ Intensive Care Med2005
Hyper- and Hypo- natremiaManagement of Hyponatremia in the ICU.Sterns RHChest2013
Hyper- and Hypo- natremiaHypernatremiaAdrogue HJNew Engl J Med2000
HypoxemiaGuidelines for standards of care for patients with acute respiratory failure on mechanical ventilatory support. Task Force on Guidelines; Society of Critical Care MedicineSociety of Critical Care MedicineCrit Care Med.1991
Myxedema comaMyxedema coma: a new look into an old crisis.Chowdhury SJ Thyroid Res2011
Neuroleptic Malignant SyndromeNeuroleptic Malignant Syndrome.Strawn JRAm J Psychiatry2007
NutritionGuidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill PatientSociety of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)J Parenter Enteral Nutr.2009
NutritionTrial of the route of early nutritional support in critically ill adults.Harvey SENew Engl J Med2014
PancreatitisAmerican College of Gastroenterology Guideline: Management of Acute PancreatitisVege SSAm J Gastroenterol2013
Post arrest Therapeutic HypothermiaTargeted Temperature Management at 33¡C versus 36¡C after Cardiac Arrest (TTM study)Nielsen NNew Engl J Med2013
Post arrest Therapeutic HypothermiaTherapeutic Hypothermia after Out-of-Hospital Cardiac Arrest in ChildrenMoler FWNew Engl J Med2015
Post arrest Therapeutic HypothermiaEffect of Prehospital Induction of Mild Hypothermia on Survival and Neurological Status Among Adults With Cardiac Arrest: A Randomized Clinical Trial.Kim FJAMA2013
Pulmonary EmbolismManagement of Massive and Submassive Pulmonary Embolism, Iliofemoral Deep Vein Thrombosis, and Chronic Thromboembolic Pulmonary Hypertension: A Statement from the American Heart Association.Jaff MRCirculation2011
Pulmonary EmbolismThrombolytic treatment for pulmonary embolism.Dong BCochrane Database2006
Pulmonary EmbolismSubcutaneous low-molecular-weight-heparin compared with continuous intravenous heparin in the treatment of proximal vein thrombosisHull RDNew Engl J Med1992
ResuscitationA comparison of albumin and saline for fluid resuscitation in the intensive care unit.Finfer SNew Engl J Med2004
ResuscitationComparison of dopamine and norepinephrine in the treatment of shock.De Backer DNew Engl J Med
ResuscitationPreoxygenation and Prevention of Desaturation During Emergency Airway ManagementWeingart SDAnnals of Emergency Medicine2012
Sepsis/Septic ShockEarly goal directed therapy in the treatment of severe sepsis and septic shock.Rivers MNew Engl J Med2001
Sepsis/Septic ShockA Randomized Trial of Protocol-Based Care for Early Septic Shock (ProCESS study)The ProCESS InvestigatorsNew Engl J Med2014
Sepsis/Septic ShockLactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis TherapyJones AEJAMA2010
Sepsis/Septic ShockFluid resuscitation in severe sepsis and septic shock: an evidence-based reviewVincent JLCrit Care Med2004
Status epilepticusLorazepam vs Diazepam for Pediatric Status Epilepticus: A Randomized Clinical Trial.Chamberlain JMJAMA2014
Status epilepticusAnticonvulsant therapy for status epilepticusPrasad MCochrane2014
Status epilepticusStatus EpilepticusCherian AAnnals of Indian Academy of Neurology2009
Thyroid stormClinical concepts on thyroid emergenciesPapi GFront Endocrinol2014
ToxicologyIntravenous lipid emulsion in clinical toxicologyRothschild LScandiv Jrnl of Trauma, Resus, and Em Med2010
ToxicologyToxicology in the ICU: Part 1: General Overview and Approach to TreatmentLevine MChest2011
ToxicologyToxicology in the ICU: Part 2: Specific ToxinsBrooks DEChest2011
ToxicologySerotonin toxicity: a practical approach to diagnosis and treatment.Isbister GKMJA2007
ToxicologyTricyclic antidepressant overdose: a review.Kerr GWEmerg Med J2001
ToxicologyAn evidence based flowchart to guide the management of acute salicylate (aspirin) overdoseDargan PIEmerg Med J2002
ToxicologyA review of acetaminophen poisoning.Hodgman MJCrit Care Clin2012
ToxicologyTreatment for calcium channel blocker poisoning: A systematic reviewSt-onge MClinical Toxicology2014
ToxicologyManagement of acute organophosphorus pesticide poisoningEddleston MLancet2008
ToxicologyA Systematic Review of Ethanol and Fomepizole Use in Toxic Alcohol IngestionsBeatty LEmerg Med International2013
ToxicologyReview article: Management of cyanide poisoning.Reade MCEmerg Med Australia2012
Upper GI/Variceal BleedingManagement of Gastric VaricesGarcia-Pagan JCClinical Gastroenterology and Hepatology2014
Upper GI/Variceal BleedingOmeprazole before endoscopy in patients with gastrointestinal bleeding.Lau JYNew Engl J Med2007
Upper GI/Variceal BleedingTransfusion Strategies for Acute Upper Gastrointestinal Bleeding.Villanueva CNew Engl J Med2013
Danish Malik, MD

Danish Malik, MD

Resident Physician, Mt. Sinai St. Luke’s–Roosevelt Hospital, New York, NY
Cassidy Dahn, MD

Cassidy Dahn, MD

Resident Physician, Boston University Medical Center, Boston, MA
Cassidy Dahn, MD

Latest posts by Cassidy Dahn, MD (see all)

Ann Tsung, MD

Ann Tsung, MD

Resident Physician, University of Florida
Ann Tsung, MD

Latest posts by Ann Tsung, MD (see all)

Zach Jarou, MD
Zach Jarou is a resident physician at Denver Health Medical Center and the Department of Emergency Medicine at the University of Colorado School of Medicine. He is the 2017-2018 President of the Emergency Medicine Residents' Association. He has previously served as EMRA's President-Elect, Membership Development Coordinator, Medical Student Council Chair, and as a member of ACEP's National-Chapter Relations Committee.
Zach Jarou, MD

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